Department of Clinical Research and Department of Nephrology and Hypertension, Inselspital, University of Bern Medical School, 3010 Bern, Switzerland.
J Oncol. 2012;2012:141236. doi: 10.1155/2012/141236. Epub 2011 Sep 5.
During the past 20 years, the phosphatase and tensin homolog PTEN has been shown to be involved in major physiological processes, and its mutation or loss is often associated with tumor formation. In addition PTEN regulates angiogenesis not only through its antagonizing effect on the PI3 kinase pathway mainly, but also through some phosphatase-independent functions. In this paper we delineate the role of this powerful tumor suppressor in tumor angiogenesis and dissect the underlying molecular mechanisms. Furthermore, it appears that, in a number of cancers, the PTEN status determines the response to chemotherapy, highlighting the need to monitor PTEN expression and to develop PTEN-targeted therapies.
在过去的 20 年中，磷酸酶和张力蛋白同系物（PTEN）已被证明参与了主要的生理过程，其突变或缺失通常与肿瘤形成有关。此外，PTEN 通过其对 PI3 激酶途径的拮抗作用以及一些非磷酸酶依赖性功能来调节血管生成。在本文中，我们阐述了这种强大的肿瘤抑制因子在肿瘤血管生成中的作用，并剖析了其潜在的分子机制。此外，在许多癌症中，PTEN 的状态决定了对化疗的反应，这凸显了监测 PTEN 表达和开发 PTEN 靶向治疗的必要性。
