University of Houston, Department of Biology and Biochemistry, 369 SR2, Houston, TX 77204-5001, USA.
Int Rev Neurobiol. 2011;99:87-105. doi: 10.1016/B978-0-12-387003-2.00004-5.
Male courtship in Drosophila melanogaster is a robust innate behavior that is shaped by sensory input and experience. It is regulated by the general sex-determination pathway through the sex-specific forms of fruitless and doublesex. Recent findings have shown that both fruitless and doublesex are required for courtship. This chapter reviews the role of these proteins and the neurons that express them in the regulation of courtship behavior. In particular it discusses how doublesex and fruitless contribute to the generation of sexually dimorphic neurons, the role of cell death, and the emerging information about circuits that underlie the behavior.
果蝇的雄性求爱行为是一种强大的先天行为，受感官输入和经验的影响。它通过一般的性别决定途径调节，途径中涉及到特异性的 fruitless 和 doublesex 基因。最近的研究表明，fruitless 和 doublesex 都对求爱行为起作用。本章回顾了这些蛋白和表达它们的神经元在求爱行为调控中的作用。特别是，它讨论了 doublesex 和 fruitless 如何促进性别二态性神经元的产生，细胞死亡的作用，以及关于行为基础的回路的新兴信息。
