Council of Scientific and Industrial Research - Central Leather Research Institute, Industrial Chemistry Laboratory, Adyar, Chennai 600020, India.
Colloids Surf B Biointerfaces. 2011 Dec 1;88(2):779-84. doi: 10.1016/j.colsurfb.2011.08.017. Epub 2011 Aug 25.
The aggregation behavior and interaction of an amphiphilic antidepressant drug imipramine (IMP) hydrochloride with the cationic surfactant cetyltrimethylammonium bromide (CTAB) have been studied using light scattering (both static and dynamic) techniques. Due to rigid tricyclic hydrophobic moiety present in the molecule, the drug shows interesting association behavior. The static light scattering measurements show that the self-association of IMP commenced above a well-defined critical micellar concentration (CMC), which decreases with increasing the mole fraction of the CTAB surfactant. Both the excess Gibbs energy (ΔG(ex)) and the Gibbs energy of micellization (ΔG(M)°) are negative, and decrease with increasing mole fraction of the surfactant. The hydrodynamic diameters (d(h)) of the micellar aggregates were also evaluated using the dynamic light scattering measurements. The data indicate formation of larger aggregates by IMP and CTAB due to mixed micellization and subsequent micellar growth. The results have been analyzed using different models (viz., Clint, Motomura, Rosen, Rubingh, etc.) for mixed micelle formation.
采用光散射（静态和动态）技术研究了两亲性抗抑郁药盐酸丙咪嗪（IMP）与阳离子表面活性剂十六烷基三甲基溴化铵（CTAB）的聚集行为和相互作用。由于分子中存在刚性三环疏水性部分，该药物表现出有趣的聚集行为。静态光散射测量表明，IMP 的自组装在明确定义的临界胶束浓度（CMC）以上开始，随着 CTAB 表面活性剂摩尔分数的增加而降低。超额吉布斯自由能（ΔG(ex)）和胶束化吉布斯自由能（ΔG(M)°）均为负值，并随表面活性剂摩尔分数的增加而降低。还使用动态光散射测量评估了胶束聚集体的水动力直径（d(h)）。数据表明，由于混合胶束化和随后的胶束生长，IMP 和 CTAB 形成了更大的聚集体。结果已使用不同的模型（即，Clint、Motomura、Rosen、Rubingh 等）进行了混合胶束形成的分析。
