氨曲南/甲硝唑与头孢噻肟/甲硝唑用于择期结直肠手术的比较：抗菌预防必须包括革兰氏阳性菌覆盖。
A comparison of aztreonam/metronidazole and cefotaxime/metronidazole in elective colorectal surgery: antimicrobial prophylaxis must include gram-positive cover.
作者信息
Morris D L, Wilson S R, Pain J, Edwardson K F, Jones J, Strachan C, Slack R
机构信息
Department of Surgery, University Hospital Nottingham, UK.
出版信息
J Antimicrob Chemother. 1990 Apr;25(4):673-8. doi: 10.1093/jac/25.4.673.
Aztreonam/metronidazole and cefotaxime/metronidazole were compared in a prospective trial in 154 patients undergoing elective colorectal surgery. Three antibiotic doses were given over 16 hours. A significant excess of wound sepsis in the aztreonam group was seen (23/71 vs 9/70 chi 2 6.60; P less than 0.01). Sepsis was almost invariably due to Gram-positive organisms and, in particular, Staphylococcus aureus.
在一项针对154例接受择期结肠直肠手术患者的前瞻性试验中，对氨曲南/甲硝唑和头孢噻肟/甲硝唑进行了比较。在16小时内给予三种抗生素剂量。结果发现氨曲南组伤口感染明显过多（23/71对9/70，卡方值6.60；P<0.01）。感染几乎均由革兰氏阳性菌引起，尤其是金黄色葡萄球菌。
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