Matrix² 线圈在颅内动脉瘤栓塞中的应用：单中心 1 年结果及与裸铂线圈组的比较。
Matrix² coils in embolization of intracranial aneurysms: 1-year outcome and comparison with bare platinum coil group in a single institution.
机构信息
Department of Radiology, Catholic University of Daegu Medical Center, Daegu, Korea.
出版信息
AJNR Am J Neuroradiol. 2011 Oct;32(9):1745-50. doi: 10.3174/ajnr.A2579. Epub 2011 Sep 15.
BACKGROUND AND PURPOSE
The endosaccular occlusion by using BPC has been useful in the treatment of intracranial aneurysms, but its limited durability remains a deep-seated drawback. The Matrix² coil, one of the bioactive-coated coils, had been developed to improve this limited durability. To evaluate durability of Matrix² coils after embolization of intracranial aneurysms, we retrospectively compared 1-year outcomes with that of BPC groups.
MATERIALS AND METHODS
A group of 121 aneurysms in 114 patients were embolized by using Matrix² coils between April 2006 and September 2008. The BPC group consisted of 151 aneurysms in 137 patients embolized by using BPCs alone between October 2007 and October 2008. The initial outcomes including packing densities, occlusion grades, and periprocedural complications, and the 1-year outcomes on MR angiography were retrospectively compared between the 2 groups.
RESULTS
The Matrix² coil group and BPC group with similar baseline demographic characteristics revealed comparable initial outcomes. The rates of overall recurrence, major recanalization, and retreatment were 17.4%, 14.0%, and 10.7% versus 7.3%, 5.3%, and 4.6%, respectively (P = .066). However, the rates of subgroups with aneurysm volumes between 50 and 200 mm³ were 23.7%, 13.1%, and 10.5% versus 2.2%, 0%, and 0% (P = .022), respectively. The rates of subgroups with packing attenuation <30% were 38.3%, 31.9%, and 23.4% versus 13.3%, 11.7%, and 10% (P = .025), respectively. There were no differences in packing attenuation (P = .152), initial occlusion grade (P = .098), and 1-year outcomes (P = .209) according to the length of Matrix² coils used.
CONCLUSIONS
Overall, initial and 1-year outcomes of the Matrix² coil group were comparable to those of the BPC group. However, in certain subgroups of aneurysm volume and packing attenuation, the 1-year durability of Matrix² coils was inferior to that of the BPC group.
背景与目的
使用 BPC 进行囊内闭塞已被证明对颅内动脉瘤的治疗是有效的，但它的耐用性有限仍是一个严重的缺点。Matrix² 线圈是一种生物活性涂层线圈，旨在提高这种有限的耐用性。为了评估 Matrix² 线圈栓塞颅内动脉瘤后的耐用性，我们回顾性比较了 1 年的结果与 BPC 组的结果。
材料与方法
2006 年 4 月至 2008 年 9 月期间，114 例患者的 121 个动脉瘤使用 Matrix² 线圈栓塞。BPC 组由 2007 年 10 月至 2008 年 10 月期间单独使用 BPC 栓塞的 137 例患者的 151 个动脉瘤组成。回顾性比较了两组的初始结果（包括填塞密度、闭塞程度和围手术期并发症）和 1 年的磁共振血管造影结果。
结果
具有相似基线人口统计学特征的 Matrix² 线圈组和 BPC 组具有可比的初始结果。总的复发率、主要再通率和再治疗率分别为 17.4%、14.0%和 10.7%与 7.3%、5.3%和 4.6%（P =.066）。然而，动脉瘤体积在 50 至 200mm³之间的亚组的复发率分别为 23.7%、13.1%和 10.5%与 2.2%、0%和 0%（P =.022）。填塞衰减<30%的亚组的复发率分别为 38.3%、31.9%和 23.4%与 13.3%、11.7%和 10%（P =.025）。使用 Matrix² 线圈的长度不同，填塞衰减（P =.152）、初始闭塞程度（P =.098）和 1 年结果（P =.209）均无差异。
结论
总的来说，Matrix² 线圈组的初始和 1 年结果与 BPC 组相当。然而，在某些动脉瘤体积和填塞衰减的亚组中，Matrix² 线圈的 1 年耐用性劣于 BPC 组。
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