蛋白激酶C-θ的双重性：对人类T细胞生物学的新见解。
Duplicity of protein kinase C-θ: Novel insights into human T-cell biology.
作者信息
Sutcliffe Elissa L, Rao Sudha
机构信息
Discipline of Biomedical Sciences; Faculty of Applied Science; University of Canberra; Canberra, Australia.
出版信息
Transcription. 2011 Jul;2(4):189-192. doi: 10.4161/trns.2.4.16565.
Abstract
We recently reported on a new wrinkle of complexity in how eukaryotic genes are regulated by providing evidence for a hitherto unknown nuclear function of the signaling kinase, Protein Kinase C-theta (PKC-θ). This chromatin-anchored complex positively regulates inducible immune genes and negatively regulates target miRNA genes. These data challenge the traditional view of mammalian signaling kinases and provides new avenues for therapeutic drug design.
摘要
我们最近报道了真核基因调控复杂性方面的一个新情况，即通过提供证据证明信号激酶蛋白激酶C-θ（PKC-θ）迄今未知的核功能。这种与染色质锚定的复合物对诱导性免疫基因起正向调控作用，而对靶标miRNA基因起负向调控作用。这些数据挑战了哺乳动物信号激酶的传统观点，并为治疗药物设计提供了新途径。
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