一项关于二氧化碳或室内空气泡沫硬化疗法治疗下肢网状静脉的副作用及疗效的研究：一项试点研究。
An investigation of side-effects and efficacy of foam-based sclerotherapy with carbon dioxide or room air in the treatment of reticular leg veins: a pilot study.
作者信息
Peterson J D, Goldman M P
机构信息
Dermatology Cosmetic Laser Associates of La Jolla, San Diego, CA 92121, USA.
出版信息
Phlebology. 2012 Mar;27(2):73-6. doi: 10.1258/phleb.2011.010073. Epub 2011 Sep 16.
OBJECTIVES
In sclerotherapy, carbon dioxide (CO(2)) or room air can be employed by phlebologists for foam creation. We compared room air (RA) and carbon dioxide in treating reticular leg veins with foam sclerotherapy.
METHODS
Twenty patients were randomly treated with RA- or CO(2)-created sodium tetradecyl sulphate (STS) foam. Concentration and volume of STS, side-effects and efficacy were determined.
RESULTS
There was no difference in the efficacy, local side-effects or distant side-effects between RA and CO(2) foam in the treatment of reticular leg veins. The total volume of foam sclerosant required for treatment was greater with CO(2) compared with RA (P value = 0.01).
CONCLUSION
No differences were found in efficacy or side-effects between RA- and CO(2)-foam sclerotherapy for reticular leg veins. CO(2) foam's shorter half-life was hypothesized to be responsible for larger total volumes of CO(2) foam sclerosant.
目的
在硬化治疗中，静脉病专家可使用二氧化碳（CO₂）或室内空气来制备泡沫。我们比较了在泡沫硬化治疗网状腿部静脉时使用室内空气（RA）和二氧化碳的情况。
方法
20例患者被随机采用由室内空气或二氧化碳制备的十四烷基硫酸钠（STS）泡沫进行治疗。测定了STS的浓度和体积、副作用及疗效。
结果
在治疗网状腿部静脉时，室内空气泡沫和二氧化碳泡沫在疗效、局部副作用或远处副作用方面没有差异。与室内空气相比，二氧化碳治疗所需的泡沫硬化剂总体积更大（P值 = 0.01）。
结论
在网状腿部静脉的室内空气泡沫和二氧化碳泡沫硬化治疗之间，未发现疗效或副作用存在差异。据推测，二氧化碳泡沫较短的半衰期导致了二氧化碳泡沫硬化剂总体积较大。
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