尿路病原体中产超广谱β-内酰胺酶的检测
Detection of Extended Spectrum β-lactamase Production Among Uropathogens.
作者信息
Aggarwal Ritu, Chaudhary Uma, Sikka Rama
机构信息
Department of Microbiology, Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak-124 001, Haryana, India.
出版信息
J Lab Physicians. 2009 Jan;1(1):7-10. doi: 10.4103/0974-2727.44423.
BACKGROUND
Detection of extended spectrum β-lactamase (ESBL) production among uropathogens is an important marker of endemicity.
AIM
Intervention of this endemic transmission is important for the control of initial outbreak of ESBL producing organisms in a hospital or specialized unit of hospital.
MATERIALS AND METHODS
During the study period of one and a half months, 1,551 urine samples were processed for significant bacteriuria. Two hundred gram negative bacterial isolates were tested for ESBL production. Antimicrobial sensitivity pattern was ascertained for ESBL producing isolates.
RESULTS
ESBL production was seen in 36% of isolates. All the isolates were multidrug resistant with uniform sensitivity to imipenem.
CONCLUSION
This study reveals the significant prevalence of ESBL producing organisms in this north Indian tertiary care hospital. Constant revision of antibiotic policies with infection control interventions is suggested.
背景
检测尿路病原体中产超广谱β-内酰胺酶（ESBL）是地方流行性的一个重要指标。
目的
干预这种地方传播对于控制医院或医院专科单位中产ESBL生物体的初次暴发很重要。
材料与方法
在为期一个半月的研究期间，对1551份尿液样本进行了显著菌尿检测。对200株革兰氏阴性菌分离株进行了ESBL产生检测。确定了产ESBL分离株的抗菌敏感性模式。
结果
36%的分离株产ESBL。所有分离株均对多种药物耐药，对亚胺培南有一致的敏感性。
结论
本研究揭示了这家印度北部三级护理医院中产ESBL生物体的显著流行率。建议不断修订抗生素政策并采取感染控制干预措施。
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