Faculty of Economic Sciences and Management, Open University of Cyprus.
Hellenic J Cardiol. 2011 Sep-Oct;52(5):407-15.
Cardiovascular diseases and hypertension may have a significant impact on the quality of life of those who suffer from these conditions. The aim of the present study was to measure health-related quality of life among Cypriot patients suffering from hypertension and/or dyslipidaemia, as well as to investigate any temporal changes in their quality of life at 3 and 6 months from the initial visit.
A stratified random sampling method was used in this follow-up multi-centre study to select a representative sample of physicians who treat patients with hypertension in both public and private sector outpatient hospital clinics and physician offices. The participants were diagnosed by the physician according to the 2007 European guidelines for the management of arterial hypertension. The EQ-5D questionnaire was employed to measure self-assessed quality of life among these patients. Six hundred and fifty-four patients were recruited by physicians and agreed to participate, while 528 of them successfully completed EQ-5D at baseline and two subsequent phases (at 3 and 6 months), representing a response rate of 80.7%.
A total of 39.6% of the respondents reported problems in one or more of the EQ-5D dimensions. This was more apparent in the case of anxiety and depression. There appeared to be statistically significant improvements with regard to mobility, usual activities, pain/discomfort and anxiety/depression dimensions between the initial visit and on first follow up, as well as subsequently. Median (interquartile range) EQ-5D index scores were 0.97 (0.19), 0.97 (0.19) and 0.97 (0.17) at first visit, first follow-up and second followup respectively (p<0.001). Also, median EQ-5D VAS scores were 80 (20), 85 (10) and 90 (15) at the initial, first follow-up and second follow-up visit respectively (p<0.001). Median EQ-5D VAS scores increased over time amongst all socio-demographic and risk groups of participants.
Hypertension had little association with mobility and physical activities, indicating that performing physical activities was not limited by hypertension. However, hypertension seems to be more strongly related to anxiety and depression.
心血管疾病和高血压可能会对患有这些疾病的人的生活质量产生重大影响。本研究的目的是测量塞浦路斯高血压和/或血脂异常患者的健康相关生活质量，并调查他们在首次就诊后 3 个月和 6 个月时生活质量的任何时间变化。
本随访多中心研究采用分层随机抽样方法，选择在公共和私人部门门诊医院诊所和医生办公室治疗高血压患者的医生的代表性样本。根据 2007 年欧洲动脉高血压管理指南，医生对患者进行诊断。使用 EQ-5D 问卷来衡量这些患者的自我评估生活质量。共有 654 名医生招募的患者同意参与，其中 528 名患者在基线和随后的两个阶段（3 个月和 6 个月）成功完成了 EQ-5D，应答率为 80.7%。
共有 39.6%的受访者报告在一个或多个 EQ-5D 维度上存在问题。在焦虑和抑郁方面更为明显。在移动性、日常活动、疼痛/不适和焦虑/抑郁方面，与首次就诊时相比，首次随访时以及随后的随访时，都有统计学意义上的显著改善。中位数（四分位距）EQ-5D 指数评分分别为首次就诊时 0.97（0.19）、首次随访时 0.97（0.19）和第二次随访时 0.97（0.17）（p<0.001）。同样，EQ-5D VAS 评分中位数分别为初始时 80（20）、首次随访时 85（10）和第二次随访时 90（15）（p<0.001）。在所有社会人口统计学和风险组的参与者中，EQ-5D VAS 评分随时间增加。
高血压与移动性和体力活动的关联较小，这表明进行体力活动不受高血压的限制。然而，高血压似乎与焦虑和抑郁的关系更为密切。
