Shlimun Andrew, Unniappan Suraj
Laboratory of Integrative Neuroendocrinology, Department of Biology, York University, Toronto, ON, Canada M3J 1P3.
Int J Pept. 2011;2011:217957. doi: 10.1155/2011/217957. Epub 2011 Sep 15.
Ghrelin O-acyl transferase (GOAT) is a recently identified enzyme responsible for the unique n-acyl modification of ghrelin, a multifunctional metabolic hormone. GOAT structure and activity appears to be conserved from fish to man. Since the acyl modification is critical for most of the biological actions of ghrelin, especially metabolic functions, GOAT emerged as a very important molecule of interest. The research on GOAT is on the rise, and several important results reiterating its significance have been reported. Notable among these discoveries are the identification of GOAT tissue expression patterns, effects on insulin secretion, blood glucose levels, feeding, body weight, and metabolism. Several attempts have been made to design and test synthetic compounds that can modulate endogenous GOAT, which could turn beneficial in favorably regulating whole body energy homeostasis. This paper will focus to provide an update on recent advances in GOAT research and its broader implications in the regulation of energy balance.
胃饥饿素O-酰基转移酶（GOAT）是一种最近发现的酶，负责胃饥饿素这种多功能代谢激素独特的N-酰基修饰。从鱼类到人类，GOAT的结构和活性似乎是保守的。由于酰基修饰对胃饥饿素的大多数生物学作用至关重要，尤其是代谢功能，GOAT成为了一个非常重要的研究对象。对GOAT的研究正在兴起，并且已经报道了一些重申其重要性的重要成果。这些发现中值得注意的是GOAT组织表达模式的确定、对胰岛素分泌、血糖水平、进食、体重和代谢的影响。人们已经进行了几次尝试来设计和测试能够调节内源性GOAT的合成化合物，这可能有利于调节全身能量稳态。本文将重点介绍GOAT研究的最新进展及其在能量平衡调节方面的更广泛意义。
