内脏脂肪切除术和胃束带术对肥胖型糖尿病大鼠模型的影响。

Effects of visceral fat resection and gastric banding in an obese diabetic rat model.

机构信息

Department of Surgery I, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan.

出版信息

Surgery. 2012 Jan;151(1):6-12. doi: 10.1016/j.surg.2011.06.025. Epub 2011 Sep 22.

DOI:10.1016/j.surg.2011.06.025

PMID:21943633

Abstract

BACKGROUND

Although the function of visceral fat has gradually become clear, the effects of its resection on insulin resistance and glucose metabolism are still unknown. This study aimed to clarify the effects of visceral fat resection and gastric banding in an obese diabetic rat model.

METHODS

Forty male Zucker diabetic fatty rats were divided into 4 groups: sham operation, visceral fat resection, gastric banding, and gastric banding with visceral fat resection. The rats were followed for 8 weeks after operation, and the change in body weight, amount of food intake, metabolic parameters, insulin tolerance, oral glucose tolerance, and adipocytokines were examined.

RESULTS

Compared with the sham operation and visceral fat resection groups, the gastric banding and gastric banding + visceral fat resection groups showed significant decreases in weight gain and cumulative food intake, as well as improvement in secretion of adipocytokines and in insulin resistance. Although no differences were found between the sham operation and visceral fat resection groups in weight gain and food intake, high-molecular-weight adiponectin, tumor necrosis factor-α levels, and insulin resistance were improved in the visceral fat resection group compared with the sham operation group. The gastric banding + visceral fat resection group had greater serum levels of high-molecular-weight adiponectin than did the gastric banding group, but no difference was found between the gastric banding and gastric banding + visceral fat resection groups in insulin resistance and glucose metabolism.

CONCLUSION

In diabetic fatty rats, the surgical removal of visceral fat effected some improvement in insulin resistance and glucose metabolism. Because the effect was relatively minimal compared with that of gastric banding, visceral fat resection combined with gastric banding did not appear to exert additional effects on insulin resistance and glucose metabolism compared with gastric banding alone.

摘要

背景

尽管内脏脂肪的功能逐渐变得清晰，但它的切除对胰岛素抵抗和葡萄糖代谢的影响仍不清楚。本研究旨在阐明内脏脂肪切除和胃带术在肥胖型糖尿病大鼠模型中的作用。

方法

40 只雄性 Zucker 糖尿病肥胖大鼠随机分为 4 组：假手术组、内脏脂肪切除组、胃带组和胃带加内脏脂肪切除组。术后 8 周，观察各组大鼠体重、摄食量、代谢参数、胰岛素耐量、口服葡萄糖耐量和脂肪细胞因子的变化。

结果

与假手术组和内脏脂肪切除组相比，胃带组和胃带加内脏脂肪切除组体重增加和累积摄食量明显减少，脂肪细胞因子分泌和胰岛素抵抗改善。尽管假手术组和内脏脂肪切除组体重增加和摄食量无差异，但与假手术组相比，内脏脂肪切除组高分子量脂联素、肿瘤坏死因子-α水平和胰岛素抵抗均有所改善。胃带加内脏脂肪切除组血清高分子量脂联素水平高于胃带组，但胃带组和胃带加内脏脂肪切除组之间胰岛素抵抗和葡萄糖代谢无差异。