Department of Pharmacy and Pharmaceutical Technology, University of Seville, Seville, Spain.
Eur J Pharm Biopharm. 2012 Jan;80(1):136-42. doi: 10.1016/j.ejpb.2011.09.007. Epub 2011 Sep 17.
Percolation theory has been applied to estimate the Hypromellose (HPMC) percolation thresholds and the influence of the polymer viscosity and the initial porosity on these thresholds in carbamazepine multicomponent matrix formulations. Different batches containing two viscosity grades of HPMC as hydrophilic matrix forming polymer, MCC and lactose as fillers, and a lubricant mixture have been manufactured varying the compression pressure in order to obtain matrices with three levels of initial porosity. The results suggested the existence of an excipient percolation threshold between 13 and 15% v/v of HPMC for the different batches prepared. It has been found that the percolation threshold for this polymer is independent on the formulation factors studied in this paper: polymer viscosity and initial porosity of the matrices.
渗流理论已被应用于估算羟丙甲纤维素（HPMC）的渗流阈值，以及聚合物黏度和初始孔隙率对卡马西平多组分基质配方中这些阈值的影响。不同批次的 HPMC 含有两种黏度等级，作为亲水基质形成聚合物，MCC 和乳糖作为填充剂，以及润滑剂混合物，通过改变压缩压力来制造具有三种初始孔隙率水平的基质。结果表明，在所制备的不同批次中，存在一个介于 13%至 15%v/v 之间的赋形剂渗流阈值。已经发现，对于本文研究的制剂因素，聚合物的渗流阈值是独立的：聚合物黏度和基质的初始孔隙率。
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