Monasterio Erik, McKean Andrew
University of Otago and Hillmorton Hospital, Christchurch, New Zealand.
N Z Med J. 2011 Jun 10;124(1336):24-9.
To estimate the frequency and characteristics of "off-label" use of atypical antipsychotic medications (AAPs) by psychiatrists in Canterbury, New Zealand.
Data on "off-label" prescribing of AAPs including the choice of medication, frequency of prescribing, and the indications for its use was collected using a postal survey of psychiatrists registered with the NZ Medical Council in the Canterbury region.
48 psychiatrists (71%) completed the survey. Forty-six (96%) prescribed AAPs "off-label". By far the most common agent was quetiapine (94%). Twenty-eight respondents (58%) prescribed "off-label" at least once a week. The most common reasons for the use of these agents was: anxiety (89%), sedation (79%), post-traumatic stress disorder (57%), treatment augmentation of another antipsychotic agent (48%) and behavioural and psychological symptoms of dementia (33%).
"Off-label" prescribing, particularly of quetiapine is very common in the Canterbury region, despite little scientific evidence for this kind of use, increasing evidence of abuse and potential for significant side-effects.
评估新西兰坎特伯雷地区精神科医生使用非典型抗精神病药物（AAPs）进行“超说明书用药”的频率及特点。
采用邮寄调查问卷的方式，收集在坎特伯雷地区新西兰医学委员会注册的精神科医生关于AAPs“超说明书用药”的数据，包括药物选择、用药频率及其使用指征。
48名精神科医生（71%）完成了调查。46名（96%）医生开具了AAPs的“超说明书用药”。到目前为止，最常用的药物是喹硫平（94%）。28名受访者（58%）每周至少进行一次“超说明书用药”。使用这些药物最常见的原因是：焦虑（89%）、镇静（79%）、创伤后应激障碍（57%）、增强另一种抗精神病药物的治疗效果（48%）以及痴呆的行为和心理症状（33%）。
在坎特伯雷地区，“超说明书用药”，尤其是喹硫平的“超说明书用药”非常普遍，尽管此类用药几乎没有科学依据，且滥用证据不断增加并有产生严重副作用的可能性。
