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省级药物诊所中出现的处方药滥用模式。

Patterns of prescription drug misuse presenting to provincial drug clinics.

作者信息

Robinson Geoffrey, Judson Graeme, Loan Richard, Bevin Timothy, O'Connor Patrick

机构信息

Capital and Coast District Health Board and Medical Research Institute of New Zealand, Wellington, New Zealand.

出版信息

N Z Med J. 2011 Jun 10;124(1336):62-7.

Abstract

AIM

To survey new patients, presenting to three drug clinics, on the patterns, usage and costs of prescription pharmaceuticals.

METHOD

Consecutive patients seen by the medical staff for assessment had a 7-day history recorded for prescription drug (PD) usage, and the associated costs of these from street sources.

RESULTS

There were 37 patients (26 males) with a mean age of 34 years (21-51). Ten reported using only intravenous (IV) morphine, at a median dose of 105 mg/day (40-600), at a mean cost of 56 cents/mg. Another 12 reported methadone as their sole opioid at a median dose of 50 mg/day (27-70), at a mean cost of 81 cents/mg. A further 11 used a mixture of opioids, predominantly morphine and methadone but also dihydrocodeine (3), oxycodone (1), tramadol (1) and codeine (2). Seventeen reported also using hypnosedatives, but did not report high doses of these. The overall weekly expenditure on PDs was $367/week (0-2100).

CONCLUSIONS

Morphine and methadone remain the predominant street opioid PDs in this region. Street prices have reduced, perhaps reflecting greater drug availability in accordance with increased national prescribing of opioids. There is continuing diversion of PDs to the street which is an ongoing Public Health issue requiring coordinated responses, including improved prescribing training, pain guidelines, drug clinic policy and actions by Medsafe, Police and regulatory bodies to contain this problem.

摘要

目的

对前往三家药物诊所就诊的新患者进行调查,了解其处方药的使用模式、用量及费用情况。

方法

医务人员对连续前来评估的患者记录其7天的处方药使用史以及从街头渠道获取这些药物的相关费用。

结果

共有37名患者(26名男性),平均年龄34岁(21 - 51岁)。10人报告仅使用静脉注射吗啡,中位剂量为105毫克/天(40 - 600毫克),平均费用为0.56美元/毫克。另外12人报告美沙酮是其唯一使用的阿片类药物,中位剂量为50毫克/天(27 - 70毫克),平均费用为0.81美元/毫克。另有11人使用多种阿片类药物的混合物,主要是吗啡和美沙酮,但也包括二氢可待因(3人)、羟考酮(1人)、曲马多(1人)和可待因(2人)。17人报告还使用催眠镇静剂,但未报告高剂量使用情况。处方药的每周总支出为367美元/周(0 - 2100美元)。

结论

吗啡和美沙酮仍是该地区街头主要的阿片类处方药。街头价格有所下降,这可能反映出随着全国阿片类药物处方量增加,药物供应更加充足。处方药持续流向街头,这是一个持续存在的公共卫生问题,需要各方协同应对,包括改进处方培训、疼痛治疗指南、药物诊所政策,以及药品安全管理局、警方和监管机构采取行动来控制这一问题。

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