Garakh Zh V, Novototskiĭ-Vlasov V Iu, Zaĭtsev Iu S, Rebreĭkina A B, Strelets V B
Zh Vyssh Nerv Deiat Im I P Pavlova. 2011 Jul-Aug;61(4):444-51.
Spectral characteristic of the alpha activity (frequency of the maximum spectral peak) were comparatively studied in schizophrenic patients with predominance of positive or negative symptoms and healthy subjects in the resting state and during cognitive task performance. In patients with negative symptoms, the spectral peak frequency of the alpha activity (8-13 Hz) was decreased at rest as compared to healthy subjects in all cortical areas. In patients with positive symptoms, the peak frequency of the alpha rhythm in the occipital cortical areas was higher than in healthy subjects. The performance-induced increase in the alpha-rhythm peak frequency during cognitive tasks was less expressed in schizophrenics than in healthy subjects. A correlation of these characteristics with psychopathological symptoms was revealed. The results suggest a difference in neurophysiological mechanisms underlying positive and negative symptoms in schizophrenia.
对以阳性或阴性症状为主的精神分裂症患者以及健康受试者在静息状态和认知任务执行期间的α活动光谱特征（最大光谱峰频率）进行了比较研究。在阴性症状患者中，与健康受试者相比，所有皮质区域静息时α活动（8 - 13赫兹）的光谱峰频率均降低。在阳性症状患者中，枕叶皮质区域α节律的峰频率高于健康受试者。在认知任务期间，精神分裂症患者中α节律峰频率因任务执行而增加的程度低于健康受试者。揭示了这些特征与精神病理症状之间的相关性。结果表明精神分裂症中阳性和阴性症状背后的神经生理机制存在差异。
