FOXP1和PAX5是急性淋巴细胞白血病中罕见但反复出现的易位伙伴。
FOXP1 and PAX5 are rare but recurrent translocations partners in acute lymphoblastic leukemia.
作者信息
Put Natalie, Deeren Dries, Michaux Lucienne, Vandenberghe Peter
机构信息
Department of Human Genetics, Universitaire Ziekenhuizen Leuven, Katholieke Universiteit Leuven, Leuven, Belgium.
出版信息
Cancer Genet. 2011 Aug;204(8):462-4. doi: 10.1016/j.cancergen.2011.07.006.
Here, we report the case of a 57-year-old man, who was diagnosed with B-cell acute lymphoblastic leukemia (B-ALL). His diagnostic workup identified a translocation t(3;9)(p13;p13). This is the fifth case reported to date that involved the forkhead box P1 gene (FOXP1) and paired box gene 5 (PAX5). The PAX5-FOXP1 translocation is a nonrandom aberration, which is recurrent in both childhood and in adult B-ALL, and may contribute to leukemogenesis by blocking differentiation of hematopoietic cells into mature B-cells.
在此，我们报告一例57岁男性，其被诊断为B细胞急性淋巴细胞白血病（B-ALL）。他的诊断检查发现了t(3;9)(p13;p13)易位。这是迄今为止报道的第五例涉及叉头框P1基因（FOXP1）和配对盒基因5（PAX5）的病例。PAX5-FOXP1易位是一种非随机畸变，在儿童和成人B-ALL中均有复发，可能通过阻断造血细胞向成熟B细胞的分化而促进白血病发生。
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