Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.
Nutr Metab Cardiovasc Dis. 2013 Apr;23(4):330-6. doi: 10.1016/j.numecd.2011.07.002. Epub 2011 Oct 2.
Visfatin is associated with atherosclerosis-related diseases. We assessed in non-diabetic individuals the association of plasma visfatin levels with cardiovascular disease (CVD) risk and the atherosclerosis-related metabolic variables.
When study population (n = 179, age 49 ± 11 years) was divided according to visfatin tertiles, the 10-year CVD Framingham risk scores were significantly increased in the top visfatin tertile. We observed a positive association between visfatin tertiles with waist circumference and blood pressure, as well as with total cholesterol and triglyceride levels, but not with apolipoprotein C-III, fibrinogen or pre-beta1 high density lipoprotein (HDL). The percentage of large HDL subclasses was significantly lower and the percentage of small HDL subclasses over the HDL-C concentration was significantly higher in the top visfatin tertile compared with the other tertiles. The atherogenic small dense low density lipoprotein subclasses (sdLDL-C) were significantly increased in the top visfatin tertile compared with the lower tertiles. High sensitivity C-reactive protein (hsCRP) concentration was significantly increased in the top visfatin tertile compared with the lower tertiles. Although age and sex distribution did not differ between visfatin tertiles, the simultaneous adjustment for these parameters attenuated the significance of the differences observed in sdLDL-C and hsCRP levels. Similarly, after adjustment for hsCRP or waist circumference, only triglycerides and blood pressure levels, as well as the distribution of HDL subclasses, remained significantly different between visfatin tertiles.
Our results support a role for visfatin in the detection of subjects with many metabolic abnormalities, which result in increased CVD risk.
内脂素与动脉粥样硬化相关疾病有关。我们在非糖尿病个体中评估了血浆内脂素水平与心血管疾病（CVD）风险及与动脉粥样硬化相关的代谢变量之间的关系。
当根据内脂素三分位将研究人群（n=179，年龄 49±11 岁）进行分组时，最高内脂素三分位的 10 年 CVD Framingham 风险评分显著升高。我们观察到内脂素三分位与腰围和血压呈正相关，与总胆固醇和甘油三酯水平呈正相关，但与载脂蛋白 C-III、纤维蛋白原或前β1 高密度脂蛋白（HDL）无关。与其他三分位相比，最高内脂素三分位的大 HDL 亚类比例显著降低，HDL-C 浓度下的小 HDL 亚类比例显著升高。与较低三分位相比，最高内脂素三分位的致动脉粥样硬化小而密低密度脂蛋白亚类（sdLDL-C）显著增加。与较低三分位相比，最高内脂素三分位的高敏 C 反应蛋白（hsCRP）浓度显著升高。虽然内脂素三分位之间的年龄和性别分布没有差异，但同时调整这些参数会削弱 sdLDL-C 和 hsCRP 水平观察到的差异的显著性。同样，在调整 hsCRP 或腰围后，只有甘油三酯和血压水平以及 HDL 亚类的分布在三分位之间仍有显著差异。
我们的结果支持内脂素在检测具有多种代谢异常的个体中的作用，这些异常导致 CVD 风险增加。
