Thorogood M, Vessey M P
Department of Community Medicine and General Practice, University of Oxford, England.
Am J Obstet Gynecol. 1990 Jul;163(1 Pt 2):274-81. doi: 10.1016/0002-9378(90)90567-q.
Earlier epidemiologic studies have indicated an increase in mortality from certain cardiovascular diseases in young women associated with the use of oral contraceptives. However, since these studies were conducted, newer oral contraceptives containing less estrogen and progestogen have been widely adopted. In addition, an increasing majority of oral contraceptive use is by women under the age of 30 years. Early results from a new case-control study suggest the possibility that the risk of myocardial infarction associated with oral contraceptive use is now lower than in the past, although the previously observed small increase in the risk of subarachnoid hemorrhage appears to be unchanged.
早期的流行病学研究表明，使用口服避孕药的年轻女性中某些心血管疾病的死亡率有所上升。然而，自这些研究开展以来，雌激素和孕激素含量更低的新型口服避孕药已被广泛采用。此外，使用口服避孕药的女性中，30岁以下的占比越来越高。一项新的病例对照研究的早期结果表明，与过去相比，现在使用口服避孕药导致心肌梗死的风险可能更低，尽管之前观察到的蛛网膜下腔出血风险略有增加的情况似乎没有变化。
