School of Pharmacy, Yantai University, Yantai.
Int J Nanomedicine. 2011;6:2053-61. doi: 10.2147/IJN.S24344. Epub 2011 Sep 20.
The ABC phenomenon is described as a syndrome of accelerated clearance of polyethylene glycol (PEG)-modified liposomes from the bloodstream when repeatedly injected, with their increased accumulation in the liver and spleen.
To clarify this immune response phenomenon, we evaluated a novel modified pH-sensitive liposome with a cleavable double smart PEG-lipid derivative (mPEG-Hz-CHEMS).
The ABC phenomenon in mice was brought about by repeated injection of conventional PEG-PE liposomes and was accompanied by a greatly increased uptake in the liver. However, a slight ABC phenomenon was brought about by repeated injection of mPEG-CHEMS liposomes and was accompanied by only a slightly increased uptake in the liver, and repeated injection of mPEG-Hz-CHEMS liposomes did not induce the ABC phenomenon and there was no increase in liver accumulation. This finding indicates that the cleavable mPEG-Hz-CHEMS derivative could lessen or eliminate the ABC phenomenon induced by repeated injection of PEGylated liposomes.
This research has shed some light on a solution to the ABC phenomenon using a cleavable PEG-Hz-CHEMS derivative encapsulated in nanoparticles.
ABC 现象被描述为当聚乙二醇（PEG）修饰的脂质体被反复注射时，其从血液中清除速度加快的综合征，同时其在肝脏和脾脏中的积累增加。
为了阐明这种免疫反应现象，我们评估了一种新型的具有可切割的双智能 PEG-脂质衍生物（mPEG-Hz-CHEMS）的改良 pH 敏感脂质体。
在小鼠中，ABC 现象是由重复注射常规 PEG-PE 脂质体引起的，同时肝脏摄取量大大增加。然而，重复注射 mPEG-CHEMS 脂质体引起的 ABC 现象较轻，仅伴有肝脏摄取量略有增加，而重复注射 mPEG-Hz-CHEMS 脂质体不会引起 ABC 现象，也不会增加肝脏积累。这一发现表明，可切割的 mPEG-Hz-CHEMS 衍生物可减轻或消除重复注射 PEG 化脂质体引起的 ABC 现象。
本研究为使用可切割的 PEG-Hz-CHEMS 衍生物包封的纳米颗粒解决 ABC 现象提供了一些思路。
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