Pan Xiang-dong, Wei Jing, Xiao Guo-min
Lin'an Hospital of Traditional Chinese Medicine, Lin'an, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Sep;40(5):522-6. doi: 10.3785/j.issn.1008-9292.2011.05.010.
To investigate the effect of β-lactam antibiotics ceftriaxone on the levels of glutamate in hippocampus following traumatic brain injury in rat.
Rats were divided randomly into three groups:sham group; trauma group and trauma+ceftriaxone group. Rats in the later two groups were subjected to a lateral cortical impact injury caused by a free-falling object, and trauma+ceftriaxone group was treated with ceftriaxone immediately after injury. The levels of glutamate in hippocampus was determined by HPLC at 12 h after trauma; the pathological change at 24 h after trauma was examined and water content of brain tissue at 3, 12 and 24 h after trauma was measured in three groups.
Compared with the trauma group,the water content in brain tissue (P<0.05), neuronal death in hippocampus CAl area and the levels of glutamate and aspartate in hippocampus at 12 h (P<0.05) were significantly decreased in trauma+ceftriaxone group.
β-lactam antibiotics ceftriaxone can reduce the level of brain glutamate, brain edema and neuronal death after traumatic brain injury in rat.
探讨β-内酰胺类抗生素头孢曲松对大鼠创伤性脑损伤后海马谷氨酸水平的影响。
将大鼠随机分为三组：假手术组；创伤组和创伤+头孢曲松组。后两组大鼠接受自由落体物体引起的侧皮质撞击损伤，创伤+头孢曲松组在损伤后立即用头孢曲松治疗。创伤后12小时通过高效液相色谱法测定海马谷氨酸水平；检查创伤后24小时的病理变化，并测量三组创伤后3、12和24小时的脑组织含水量。
与创伤组相比，创伤+头孢曲松组脑组织含水量（P<0.05）、海马CA1区神经元死亡以及创伤后12小时海马谷氨酸和天冬氨酸水平（P<0.05）均显著降低。
β-内酰胺类抗生素头孢曲松可降低大鼠创伤性脑损伤后的脑谷氨酸水平、脑水肿和神经元死亡。
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