BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
Bioorg Med Chem Lett. 2011 Nov 15;21(22):6641-5. doi: 10.1016/j.bmcl.2011.09.069. Epub 2011 Sep 22.
A Phenotypic Drug Discovery strategy was applied to study a set of pyrimidine analogs prepared by means of intramolecular oxidation-reduction reactions of N-substituted-N-(2,6-disubstituted-5-nitro-4-pyrimidinyl)aminoacetic acid methyl esters in basic media. The combined and rational use of specific assays allowed in short time reducing from all possible cellular targets to those involved in metaphase to anaphase transition.
采用表型药物发现策略研究了一组嘧啶类似物，这些类似物是通过 N-取代-N-(2,6-二取代-5-硝基-4-嘧啶基)氨 基乙酸甲酯在碱性介质中的分子内氧化还原反应制备的。通过合理地联合使用特定的检测方法，我们能够在短时间内将所有可能的细胞靶标缩小到参与中期到后期过渡的靶标。
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