Kolb E
Wissenschaftsbereich Tierbiochemie, Sektion Tierproduktion und Veterinärmedizin der Karl-Marx-Universität, Leipzig.
Z Gesamte Inn Med. 1990 Apr 15;45(8):205-10.
Some newer knowledge concerning the metabolism of the ascorbic acid as well as its importance for the pituitary gland, the adrenal glands, the immune system and the bone formation are described. A large enrichment of the ascorbic acid is present in the pituitary gland and in the adrenal glands. In the pituitary gland the compound is constituent of the Cu-containing peptidyl-glycine-alpha-amidizating-monooxygenase which among others is necessary for the formation of alpha-MSH a lack of ascorbic acid diminishes the formation of alpha-MSH at stress the increased binding of ACTH to the cells of the middle and inner layer of the adrenal cortex leads to the fact that about 40 to 60% of the quantity of ascorbic acid are delivered. This evokes an increase of the activity of the adenylate cyclase as well as of the C21-hydroxylase: The synthesis and secretion of glucocorticosteroids increases. When there is a deficiency of ascorbic acid the content of cortisol in the plasma increases. The ascorbic acid is a constituent of the dopamine-beta-hydroxylase.
描述了一些关于抗坏血酸代谢及其对垂体、肾上腺、免疫系统和骨形成重要性的新知识。垂体和肾上腺中存在大量抗坏血酸。在垂体中，该化合物是含铜肽基甘氨酸-α-酰胺化单加氧酶的组成部分，该酶对α-MSH的形成是必需的，抗坏血酸缺乏会减少应激时α-MSH的形成，促肾上腺皮质激素与肾上腺皮质中层和内层细胞的结合增加导致约40%至60%的抗坏血酸被释放。这会引起腺苷酸环化酶以及C21-羟化酶活性的增加：糖皮质激素的合成和分泌增加。当抗坏血酸缺乏时，血浆中皮质醇的含量会增加。抗坏血酸是多巴胺-β-羟化酶的组成部分。
