4-氨基-2(1H)-喹唑啉酮和 2,4(1H,3H)-喹唑啉二酮衍生物的合成、分子模拟及抗肿瘤活性评价。
Synthesis, molecular modelling and biological evaluation of 4-amino-2(1H)-quinazolinone and 2,4(1H,3H)-quinazolidone derivatives as antitumor agents.
机构信息
Department of Pharmaceutical Chemistry, Heinrich Heine University, Düsseldorf, Germany.
出版信息
Arch Pharm (Weinheim). 2011 Dec;344(12):810-20. doi: 10.1002/ardp.201000312. Epub 2011 Oct 11.
PMID:21987492
Abstract
A series of 6-benzoyl-, 6-arylthio- and 6-arylsulfonyl-4-amino-2(1H)-quinazolinones and -2,4(1H,3H)-quinazolinediones were prepared. They were evaluated in vitro for their cytotoxicity against the NCI-60 cancer cell lines.
摘要
合成了一系列 6-苯甲酰基、6-芳硫基和 6-芳磺酰基-4-氨基-2(1H)-喹唑啉酮和-2,4(1H,3H)-喹唑二酮。并对它们进行了体外细胞毒性测试，评估了它们对 NCI-60 癌细胞系的活性。
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