Goossens Nicolas, Negro Francesco
Service de gastroentérologie et d'hépatologie, Département des spécialités, HUG, 1211 Genève 14.
Rev Med Suisse. 2011 Sep 7;7(307):1683-8.
The hepatitis C virus (HCV) is a global major health burden, its response to current treatment is unfortunately inadequate, in particular for genotype 1. Two new direct acting antivirals, that inhibit NS3/4A viral protease, will soon be available on the Swiss market: telaprevir and boceprevir. These substances increase the rate of sustained viral response, in HCV genotype 1 infected patients, when coadministered with pegylated interferon and ribavirin. However, these new molecules may lead to serious adverse effects and drug interactions with which the specialist and the primary care physician must be familiar.
丙型肝炎病毒(HCV)是一项全球性的重大健康负担,遗憾的是,目前针对它的治疗效果并不理想,尤其是对1型基因型而言。两种新型直接作用抗病毒药物即将在瑞士市场上市,它们可抑制NS3/4A病毒蛋白酶,即特拉匹韦和博赛匹韦。当与聚乙二醇化干扰素和利巴韦林联合使用时,这些药物可提高1型基因型丙型肝炎病毒感染患者的持续病毒学应答率。然而,这些新分子可能会导致严重的不良反应和药物相互作用,专科医生和初级保健医生必须对此有所了解。