RNA 编辑及其在丁型肝炎病毒复制中的调控。

RNA editing and its control in hepatitis delta virus replication.

机构信息

Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA.

出版信息

Viruses. 2010 Jan;2(1):131-146. doi: 10.3390/v2010131. Epub 2010 Jan 12.

DOI:10.3390/v2010131

PMID:21994604

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3185552/

Abstract

The hepatitis delta virus genome is a small circular RNA, similar to viroids. Although HDV contains a gene, the protein produced (HDAg) is encoded by less than half the genome and possesses no RNA polymerase activity. Because of this limited coding capacity, HDV relies heavily on host functions and on structural features of the viral RNA-very much like viroids. The virus' use of host RNA editing activity to produce two functionally distinct forms of HDAg is a particularly good example of this reliance. This review covers the mechanisms and control of RNA editing in the HDV replication cycle.

摘要

乙型肝炎 delta 病毒基因组是一种小型环状 RNA，类似于类病毒。尽管 HDV 含有一个基因，但所产生的蛋白质（HDAg）仅由不到基因组一半的序列编码，并且不具有 RNA 聚合酶活性。由于这种有限的编码能力，HDV 严重依赖于宿主功能和病毒 RNA 的结构特征——非常类似于类病毒。该病毒利用宿主 RNA 编辑活性产生两种具有不同功能的 HDAg 形式，就是这种依赖性的一个很好的例子。本文综述了 HDV 复制周期中 RNA 编辑的机制和调控。