丙型肝炎病毒非结构蛋白 2（NS2）：一个崭露头角的抗病毒药物靶点。
The Hepatitis C Virus Nonstructural Protein 2 (NS2): An Up-and-Coming Antiviral Drug Target.
机构信息
Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
出版信息
Viruses. 2010 Aug;2(8):1635-1646. doi: 10.3390/v2081635. Epub 2010 Aug 6.
Infection with Hepatitis C Virus (HCV) continues to be a major global health problem. To overcome the limitations of current therapies using interferon-α in combination with ribavirin, there is a need to develop drugs that specifically block viral proteins. Highly efficient protease and polymerase inhibitors are currently undergoing clinical testing and will become available in the next few years. However, with resistance mutations emerging quickly, additional enzymatic activities or functions of HCV have to be targeted by novel compounds. One candidate molecule is the nonstructural protein 2 (NS2), which contains a proteolytic activity that is essential for viral RNA replication. In addition, NS2 is crucial for the assembly of progeny virions and modulates various cellular processes that interfere with viral replication. This review describes the functions of NS2 in the life cycle of HCV and highlights potential antiviral strategies involving NS2.
丙型肝炎病毒（HCV）感染仍然是一个全球性的主要健康问题。为了克服目前使用干扰素-α联合利巴韦林治疗的局限性，需要开发专门阻断病毒蛋白的药物。高效的蛋白酶和聚合酶抑制剂目前正在进行临床试验，将在未来几年内上市。然而，由于耐药突变迅速出现，需要新型化合物针对 HCV 的其他酶活性或功能。候选分子之一是非结构蛋白 2（NS2），它包含一种对病毒 RNA 复制至关重要的蛋白水解活性。此外，NS2 对于子代病毒颗粒的组装至关重要，并调节多种干扰病毒复制的细胞过程。本文描述了 NS2 在 HCV 生命周期中的作用，并强调了涉及 NS2 的潜在抗病毒策略。
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