铜催化亚胺碘烷介导的烯烃氨内酯化反应：在 5,5-二取代丁内酯合成中的应用。
Copper-catalyzed iminoiodane-mediated aminolactonization of olefins: application to the synthesis of 5,5-disubstituted butyrolactones.
机构信息
Institut de Chimie des Substances Naturelles, UPR 2301 CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
出版信息
Org Lett. 2011 Nov 4;13(21):5830-3. doi: 10.1021/ol202436a. Epub 2011 Oct 13.
PMID:21995549
Abstract
A copper(I)-catalyzed reaction of a variety of 4-aryl-pent-4-enoates with nosyliminoiodane generated in situ provides the corresponding 5-aryl-5-nosylamidomethylbutyrolactones. The reaction presumably proceeds via an aziridine intermediate, which could be isolated in one case.
摘要
一种铜（I）催化的多种 4-芳基-戊-4-烯酸酯与原位生成的亚硝酰基碘烷的反应，生成相应的 5-芳基-5-硝磺酰基氨甲基丁内酯。该反应可能通过氮杂环丁烷中间体进行，在一种情况下可以将其分离出来。
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