Ohnishi Kazunori
Hamamatsu University, Oncology Center, Hamamatsu, Japan.
Gan To Kagaku Ryoho. 2011 Oct;38(10):1586-90.
A half of patients with acute myeloid leukemia and lymphoma are older than 60 years. However, using chronological age for estimating chemotherapy-related risks is unreliable, and patients without comorbidity may be candidates for the standard therapy. For patients who have complex comorbidity or are older than 75 years, a reduced dose of chemotherapy or palliative treatment is appropriate. Molecular targeted therapy may be tolerable for elderly patients.
一半的急性髓系白血病和淋巴瘤患者年龄超过60岁。然而,用实际年龄来评估化疗相关风险并不可靠,没有合并症的患者可能适合标准治疗。对于有复杂合并症或年龄超过75岁的患者,减少化疗剂量或进行姑息治疗是合适的。分子靶向治疗对老年患者可能是可耐受的。