遗传和环境因素对饮食失调和抑郁症状的影响。
Genetic and environmental influences on disordered eating and depressive symptoms.
机构信息
Department of Psychology, Michigan State University, East Lansing, Michigan, USA.
出版信息
Int J Eat Disord. 2011 Nov;44(7):605-11. doi: 10.1002/eat.20867. Epub 2010 Nov 9.
OBJECTIVE
Research suggests that shared genetic factors underlie relationships between eating disorder and depression diagnoses, but no studies to date have examined these associations using dimensional symptom measures. This study examined whether genetic associations observed between eating disorder and depression diagnoses extend to continuous measures of these phenotypes.
METHOD
The sample consisted of 292 young adult female twins from the Michigan State University Twin Registry. Disordered eating was measured using the Minnesota Eating Behavior Survey. Depressive symptoms were assessed using the Beck Depression Inventory.
RESULTS
Univariate twin models indicated that genetic factors accounted for 55% to 60% of the variance in disordered eating and depressive symptoms, with the remaining variance accounted for by nonshared environmental effects. Bivariate models indicated that genetic factors primarily accounted for associations between disordered eating and depressive symptoms (r(a) = .70).
DISCUSSION
Phenotypic associations between disordered eating and depressive symptoms appear to be due to common genetic factors.
目的
研究表明，饮食失调和抑郁诊断之间存在共同的遗传因素，但迄今为止，尚无研究使用多维症状测量来检验这些关联。本研究旨在检验在饮食失调和抑郁诊断之间观察到的遗传关联是否扩展到这些表型的连续测量上。
方法
样本由密歇根州立大学双胞胎登记处的 292 名年轻成年女性双胞胎组成。饮食失调使用明尼苏达州饮食行为调查进行测量。抑郁症状使用贝克抑郁量表评估。
结果
单变量双胞胎模型表明，遗传因素占饮食失调和抑郁症状变异的 55%至 60%，其余变异由非共享环境效应解释。双变量模型表明，遗传因素主要解释了饮食失调和抑郁症状之间的关联(r(a)=.70)。
讨论
饮食失调和抑郁症状之间的表型关联似乎归因于共同的遗传因素。
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