Neuropsychopharmacologie des Addictions, INSERM U, CNRS UMR, Université PRES Sorbonne-Paris Cité, Paris, France.
Am J Addict. 2011 Nov-Dec;20(6):535-7. doi: 10.1111/j.1521-0391.2011.00181.x. Epub 2011 Oct 4.
Cocaine use is associated with the occurrence of transient psychotic symptoms. Sixteen poly-substance abusers already in treatment, who were diagnosed with crack dependence, were assessed twice: at baseline and after 3 weeks of medical management specifically aimed at cocaine abstinence. The psychotic symptoms were assessed with the French version of the Scale for Assessment of Positive Symptoms-Cocaine-Induced Psychosis (SAPS-CIP). There was a decrease of both cocaine intake and psychotic symptoms at week 3 (Wilcoxon's Z, p < .001 and .028, respectively). Furthermore, there was a significant correlation between psychotic symptoms and dose reduction (r(2) = .49, Spearman's ρ= .613, p < .012).
可卡因的使用与短暂精神病症状的发生有关。16 名已经接受治疗的多药物滥用者，被诊断为可卡因依赖，他们接受了两次评估：基线时和经过 3 周专门针对可卡因戒断的医学管理后。使用法国版的可卡因诱导精神病阳性症状评定量表（SAPS-CIP）评估精神病症状。第 3 周时，可卡因摄入量和精神病症状均下降（Wilcoxon's Z，p <.001 和.028）。此外，精神病症状与剂量减少之间存在显著相关性（r² =.49，Spearman's ρ=.613，p <.012）。
