Section of Hematology/Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Cancer Imaging. 2011 Sep 24;11(1):140-3. doi: 10.1102/1470-7330.2011.0020.
The diagnosis of leptomeningeal carcinomatosis remains difficult despite improvement in central nervous system (CNS) imaging and cytologic examination of the cerebral spinal fluid. False-negative results are common, providing obstacles in assessing both prophylactic and therapeutic efforts. As a result of increased survival of patients with a variety of systemic neoplasms it is likely that central nervous involvement will need to be addressed more often. This article presents a patient with a diffuse large B-cell lymphoma with polymorphic features. Imaging using 18F-labeled fluorodeoxythymidine (FLT) proved useful in demonstrating both parenchymal and leptomeningeal CNS involvement. The potential for FLT to identify proliferative tissue may make it uniquely suitable for detection of CNS malignant disease.
尽管中枢神经系统 (CNS) 成像和脑脊液细胞学检查有所改善，但脑脊髓膜癌的诊断仍然困难。假阴性结果很常见，这给预防性和治疗性评估都带来了障碍。由于各种系统性肿瘤患者的生存率提高，中枢神经系统受累的情况可能需要更经常地处理。本文介绍了一例弥漫性大 B 细胞淋巴瘤伴多形性特征的患者。使用 18F 标记的氟脱氧胸苷 (FLT) 进行成像，证明在显示实质和脑脊髓膜 CNS 受累方面非常有用。FLT 识别增殖组织的潜力可能使其特别适合检测 CNS 恶性疾病。
