幽门螺杆菌在婴儿肥厚性幽门狭窄发病机制中的作用。

Role of Helicobacter pylori in the pathogenesis of infantile hypertrophic pyloric stenosis.

作者信息

Aslanabadi Saeid, Rafeey Mandana, Diaz Diana, Pourhossein Davood, Ghabili Kamyar, Shoja Mohammadali M, Gupta Devendra K

机构信息

Pediatric Health Research Center, Tabriz University of Medical Sciences, Iran.

出版信息

Afr J Paediatr Surg. 2011 May-Aug;8(2):172-5. doi: 10.4103/0189-6725.86056.

DOI:10.4103/0189-6725.86056

PMID:22005359

Abstract

OBJECTIVES

To investigate the possible correlation between infantile hypertrophic pyloric stenosis (IHPS) and Helicobacter pylori infection.

MATERIALS AND METHODS

In a case-control study, 20 infants with confirmed IHPS (Group 1) and 30 age-matched healthy infants (Group 2) were enrolled for the assessment of H. pylori infection. Serological testing of anti-H. pylori antibody (IgG) was performed preoperatively on all infants and their mothers. Also, H. pylori stool antigen test (HpSA) was carried out preoperatively on all infants in both groups. Statistical analyses were performed with Chi-square test, Fisher's exact test, Mann-Whitney U test, and Independent-Samples T test.

RESULTS

There were 20 patients in group 1 (18 boys, 2 girls) and 30 infants in group 2 (30 boys). The mean age in groups 1 and 2 were 42.40±18.09 days and 44.67±12.65 days, respectively. The numbers of positive HpSA and positive anti-H. pylori antibody both in infants and mothers were comparable between the two groups (P>0.05). The median titres of H. pylori stool antigen were not comparable between the two groups (0.20 ng/dL in group 1 vs 0.57 ng/dL in group 2; P=0.02).

CONCLUSIONS

H. pylori does not seem to be in a causative linkage with IHPS.

摘要

目的

探讨婴儿肥厚性幽门狭窄（IHPS）与幽门螺杆菌感染之间可能存在的相关性。

材料与方法

在一项病例对照研究中，纳入20例确诊为IHPS的婴儿（第1组）和30例年龄匹配的健康婴儿（第2组），以评估幽门螺杆菌感染情况。对所有婴儿及其母亲在术前进行抗幽门螺杆菌抗体（IgG）的血清学检测。此外，对两组所有婴儿在术前进行幽门螺杆菌粪便抗原检测（HpSA）。采用卡方检验、Fisher精确检验、Mann-Whitney U检验和独立样本t检验进行统计分析。

结果

第1组有20例患者（18例男孩，2例女孩），第2组有30例婴儿（30例男孩）。第1组和第2组的平均年龄分别为42.40±18.09天和44.67±12.65天。两组婴儿及其母亲中HpSA阳性和抗幽门螺杆菌抗体阳性的数量相当（P>0.05）。两组之间幽门螺杆菌粪便抗原的中位滴度不可比（第1组为0.20 ng/dL，第2组为0.57 ng/dL；P=0.02）。