PMA-1 制粒机中使用粉碎机对湿高速制粒得到的颗粒的影响。
The effect of the chopper on granules from wet high-shear granulation using a PMA-1 granulator.
机构信息
Biomedical Engineering, The University of Western Ontario, London, Canada.
出版信息
AAPS PharmSciTech. 2011 Dec;12(4):1358-65. doi: 10.1208/s12249-011-9703-1. Epub 2011 Oct 18.
Chopper presence and then chopper speed was varied during wet high shear granulation of a placebo formulation using a PMA-1 granulator while also varying the impeller speed. The granules were extensively analyzed for differences due to the chopper. The effect of the chopper on the granules varied with impeller speed from no effect at a low impeller speed of 300 rpm to flow interruptions at an impeller speed of 700 rpm to minimal impact at very high impeller speeds as caking at the bowl perimeter obscured the effect of the chopper on the flow pattern. Differences in the granule flowability were minimal. However, it was concluded that the largest fraction of optimal granules would be obtained at an impeller speed of 700 rpm with the chopper at 1,000 rpm allowing balances between flow establishment, segregation, and centrifugal forces.
在使用 PMA-1 制粒机对安慰剂制剂进行湿高剪切制粒的过程中，改变切碎机的存在状态和速度，同时改变叶轮速度。对颗粒进行了广泛的分析，以研究由于切碎机而产生的差异。切碎机对颗粒的影响随叶轮速度而变化，在低叶轮速度 300 rpm 时没有影响，在叶轮速度 700 rpm 时会中断流动，在非常高的叶轮速度时影响最小，因为在碗周边结块会掩盖切碎机对流动模式的影响。颗粒流动性的差异很小。然而，结论是，在叶轮速度为 700 rpm 且切碎机速度为 1000 rpm 的情况下，将获得最大比例的最佳颗粒，从而在流动建立、分离和离心力之间取得平衡。
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