US Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Int J Tuberc Lung Dis. 2011 Nov;15(11):1553-5, i. doi: 10.5588/ijtld.11.0101.
Monthly culture is usually recommended to monitor treatment of multidrug-resistant tuberculosis (MDR-TB). As mycobacterial laboratory capacity is limited in many settings, TB programs need evidence to decide whether monthly cultures are necessary compared to other approaches. We simulated three alternative monitoring strategies (culture every 2 or 3 months, and monthly smears alone) in a cohort of MDR-TB patients in Estonia, Latvia, Philippines, Russia and Peru from 2000 to 2004. This retrospective analysis illustrated that less frequent testing delays confirmation of bacteriological conversion. This would prolong intensive treatment, hospitalization and respiratory isolation, increasing cost and toxicity. After conversion, less frequent testing could delay diagnosis of possible treatment failure.
每月培养通常被推荐用于监测耐多药结核病（MDR-TB）的治疗。由于在许多情况下分枝杆菌实验室能力有限，因此结核病规划需要有证据来确定与其他方法相比，每月进行培养是否必要。我们在 2000 年至 2004 年期间，对爱沙尼亚、拉脱维亚、菲律宾、俄罗斯和秘鲁的一组 MDR-TB 患者进行了三种替代监测策略（每 2 或 3 个月进行一次培养和仅每月进行涂片检查）的模拟。这项回顾性分析表明，较不频繁的检测会延迟细菌学转换的确认。这将延长强化治疗、住院和呼吸道隔离时间，增加成本和毒性。转换后，较不频繁的检测可能会延迟对可能治疗失败的诊断。
