Hydzik Piotr, Szpak Dorota
Klinika Toksykologii i Chorób Srodowiskowych, Uniwersytet Jagielloński, Collegium Medicum w Krakowie.
Przegl Lek. 2011;68(8):495-8.
The paper describes the case of 56 years old woman admitted to the Toxicology Department because of skin lesions, joint and muscle pain and elevated activity of transaminases and creatine phosfokinase as well in biochemical analysis. The symptoms occurred after 6 days of the Atorvastatin therapy. The clinical picture indicated side effects of the hipolipemic therapy, but the presence of the skin lesions suggested drug induced collagenosis (lupus erythrematosus, dermatomyositis). Immunological studies confirmed association with antinuclear antibodies (ANA) and anti-Mi-2 autoantibodies in the serum. Immunosuppressive therapy was ordered with clinical and biochemical improvement.
该论文描述了一名56岁女性的病例，她因皮肤病变、关节和肌肉疼痛以及生化分析中转氨酶和肌酸磷酸激酶活性升高而入住毒理学科室。这些症状在阿托伐他汀治疗6天后出现。临床表现提示为降血脂治疗的副作用，但皮肤病变的存在提示药物性胶原病（红斑狼疮、皮肌炎）。免疫学研究证实血清中存在抗核抗体（ANA）和抗Mi-2自身抗体。给予免疫抑制治疗后，临床和生化指标均有改善。
