Department of Chemical Engineering and Materials Science, Chung-Ang University, and Dongjak-gu, Seoul, Korea (South).
Drug Dev Ind Pharm. 2012 Jun;38(6):744-51. doi: 10.3109/03639045.2011.624522. Epub 2011 Oct 19.
The redispersibility of drug nanoparticles is critical in the formulation development of oral solid dosage forms from drug nanosuspensions. To address this issue, various drying techniques such as, spray drying, fluidized bed drying, etc. have been developed based on freeze drying. In this work, redispersible dried powders were successfully prepared from drug nanosuspensions without the use of dispersant by applying an electrical potential to the nozzle during the spray drying process. The applied voltage, not the concentration of the nanosuspension, was critical in determining the redispersibility. Despite the high electric field, the particle morphology and crystallinity were not dependent on the applied voltage, which suggests that the drug crystals were not damaged. This novel technique could broaden the applicability of spray drying technology and allow for novel formulations of drug nanoparticles.
药物纳米混悬液制成口服固体制剂时，其药物纳米颗粒的再分散性是关键。为了解决这个问题，已经开发了各种干燥技术，例如喷雾干燥、流化床干燥等，这些技术都是基于冷冻干燥的。在这项工作中，通过在喷雾干燥过程中向喷嘴施加电势，成功地从药物纳米混悬液中制备了无需使用分散剂的可再分散干燥粉末。施加的电压，而不是纳米混悬液的浓度，是决定再分散性的关键。尽管电场强度很高，但颗粒形态和结晶度并不依赖于所施加的电压，这表明药物晶体没有受到损伤。这项新技术可以拓宽喷雾干燥技术的适用性，并允许对药物纳米颗粒进行新的配方设计。
