Vita Salute University and Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
Neuropsychol Rehabil. 2011 Oct;21(5):742-54. doi: 10.1080/09602011.2011.614724.
This article is a selective review of functional imaging investigations and brain stimulation studies addressing the neural mechanisms of recovery of stroke-associated aphasia. The imaging results show that aphasia recovery is associated with a complex pattern of brain reorganisation, involving both ipsilateral and contralateral brain regions, which is modulated by lesion size and site, time post-onset, type of training, and language task. The information provided by the imaging investigations needs to be integrated with the results of brain stimulation studies, in order to specify the most effective protocols in term of modality, locus and timing of stimulation. Further studies, using multiple imaging and neuromodulation approaches, are required to reach sound conclusions about the potential usefulness of brain stimulation approaches as an adjunct to aphasia rehabilitation.
这是一篇选择性综述，回顾了针对卒中后失语症的神经机制的功能影像学研究和脑刺激研究。影像学结果表明，失语症的恢复与大脑重组的复杂模式相关，涉及同侧和对侧脑区，受病灶大小和位置、发病后时间、训练类型和语言任务的调节。影像学研究提供的信息需要与脑刺激研究的结果相结合，以确定刺激的模式、部位和时间等方面最有效的方案。需要进一步采用多种影像学和神经调控方法进行研究，以得出关于脑刺激方法作为失语症康复辅助手段的潜在有效性的可靠结论。
