Zenklusen H R, Weymuth G, Rist M, Mihatsch M J
Department of Pathology, Faculty of Medicine, Basel University, Switzerland.
Cancer. 1990 Sep 1;66(5):998-1001. doi: 10.1002/1097-0142(19900901)66:5<998::aid-cncr2820660533>3.0.co;2-i.
A unique triad of a carcinosarcoma and an adenocarcinoma of the prostate as well as an adenocarcinoma of the seminal vesicles in a 67-year-old man is reported. The carcinosarcoma was investigated by immunohistochemical methods. The mesenchymal parts of the sarcoma showed chondromatous differentiation expressed by S-100 protein and vimentin. The undifferentiated epithelial elements of the carcinosarcoma reacted positively to the panepithelial antibody lu-5 and to carcinoembryonic antigen (CEA). The adenocarcinoma of the prostate stained with antibodies to panepithelial antigen (lu-5), prostatic acid phosphatase, prostate specific antigen and CEA, whereas the adenocarcinoma of the seminal vesicles reacted only to lu-5 and CEA. The literature is reviewed.