Etemadifar Masoud, Mollabashi Maryam, Chitsaz Ahmad, Behnamfar Omid, Bahrami Ehsan, Minagar Alireza, Maghzi Amir-Hadi
Isfahan Neurosciences Research Centre, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Clin Neurol Neurosurg. 2012 Jan;114(1):17-20. doi: 10.1016/j.clineuro.2011.07.020. Epub 2011 Oct 19.
In this study we sought to compare the seropositivity of NMO-IgG in patients presenting with demyelinative involvement of optic nerve and spinal cord with and without longitudinally extensive spinal cord lesion (LESCL).
Patients who were referred to Isfahan Multiple Sclerosis Clinic and Isfahan Devic's Disease Clinic at Al-Zahra Hospital in Iran were screened for this study. Patients with signs and symptoms indicating the demyelinating involvement of optic nerve(s) and spinal cord were included. Patients were evaluated by a neurologist and spinal cord and brain magnetic resonance imaging (MRI) were obtained. Patients with normal first brain MRI and with spinal cord demyelinative lesions visible on spinal MRI were included. Patients were then put into two groups: (i) patients with LESCL [neuromyelitis optica (NMO)] and (ii) patients with spinal plaques which do not extend over three vertebrae [opticospinal multiple sclerosis (OSMS)]. NMO-IgG was measured in the serum of the included patients.
Totally we recruited 33 patients with LESCL and 32 patients without LESCL. The mean age of patients without LESCL was 34.61±10.98 and it was 33.48±11.93 for the NMO patients. In both groups there were 24 females and the rest were males. Among the NMO patients 16 (48.5%) were positive for NMO-IgG, while in the OSMS group there were none.
The results of this study are in line with previous observations, and imply that the presence of LESCL is associated with the presence of NMO-IgG and thus an indicator of NMO.
在本研究中，我们试图比较视神经和脊髓脱髓鞘受累且伴有或不伴有长节段脊髓病变（LESCL）的患者中NMO-IgG的血清阳性率。
对转诊至伊朗伊斯法罕扎赫拉医院的伊斯法罕多发性硬化症诊所和伊斯法罕德维克病诊所的患者进行本研究筛查。纳入有视神经和脊髓脱髓鞘受累体征和症状的患者。由神经科医生对患者进行评估，并进行脊髓和脑部磁共振成像（MRI）检查。纳入首次脑部MRI正常且脊髓MRI可见脊髓脱髓鞘病变的患者。然后将患者分为两组：（i）伴有LESCL的患者[视神经脊髓炎（NMO）]和（ii）脊髓斑块未超过三个椎体的患者[视神经脊髓型多发性硬化症（OSMS）]。检测纳入患者血清中的NMO-IgG。
我们共招募了33例伴有LESCL的患者和32例不伴有LESCL的患者。不伴有LESCL的患者平均年龄为34.61±10.98岁，NMO患者的平均年龄为33.48±11.93岁。两组中均有24名女性，其余为男性。在NMO患者中，16例（48.5%）NMO-IgG呈阳性，而在OSMS组中无一例阳性。
本研究结果与先前观察结果一致，表明LESCL的存在与NMO-IgG的存在相关，因此是NMO的一个指标。
