Women's and Children's Program, Southern Health, Melbourne, Victoria, Australia.
Fertil Steril. 2011 Dec;96(6):1514-8. doi: 10.1016/j.fertnstert.2011.09.005. Epub 2011 Oct 20.
To explore whether the predictive value of antral follicle count (AFC) changes when measured at different times during the menstrual cycle. Antimüllerian hormone (AMH) and AFC are considered to be equally predictive of poor ovarian response; however, AMH is considered to have an advantage over AFC, because AMH concentrations can be measured at any time during the menstrual cycle.
Retrospective cohort study.
Private IVF clinic.
PATIENT(S): A total of 3,117 patients with a transvaginal ultrasound within 3 months before their first IVF cycle.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Receiver operating curves (ROCs) were constructed for AFC as a screening test for poor ovarian response (fewer than four eggs collected). The areas under the curve (AUCs) were compared for ROCs from patients at different phases of the cycle.
RESULT(S): When all patients except those with polycystic ovaries were included, the AUC was 0.79. Further subgroup ROC analyses revealed that the AUCs did not differ significantly when AFC was measured at different phases of the menstrual cycle.
CONCLUSION(S): AFC can be measured regardless of the phase of the menstrual cycle without apparent effect on its predictive value for poor ovarian response.
探讨在月经周期的不同时间测量时，窦卵泡计数（AFC）的预测值是否会发生变化。抗缪勒管激素（AMH）和 AFC 被认为对卵巢反应不良具有同等的预测价值；然而，AMH 被认为优于 AFC，因为 AMH 浓度可以在月经周期的任何时间测量。
回顾性队列研究。
私人 IVF 诊所。
共有 3117 名患者在其第一次 IVF 周期前 3 个月内进行了阴道超声检查。
无。
构建 AFC 作为卵巢反应不良（采集少于 4 个卵子）的筛查试验的受试者工作特征曲线（ROC）。比较不同周期阶段患者的 ROC 曲线下面积（AUC）。
当除多囊卵巢患者外的所有患者均被纳入时，AUC 为 0.79。进一步的亚组 ROC 分析表明，在月经周期的不同阶段测量 AFC 时，AUC 没有显著差异。
无论月经周期的阶段如何，都可以测量 AFC，而不会对其预测卵巢反应不良的价值产生明显影响。
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