Risk assessment chart for curability of early gastric cancer with endoscopic submucosal dissection.

BACKGROUND

Endoscopic submucosal dissection (ESD) was introduced worldwide as a new treatment option for early gastric cancer, but curability prediction has not been evaluated on an individual basis.

OBJECTIVE

To analyze factors contributing to the curability of early gastric cancer after ESD and to construct a risk assessment chart for the probability of curability.

DESIGN

Single-institution retrospective review.

SETTING

University hospital.

PATIENTS

From June 2000 to April 2010, we treated 961 early gastric cancers in 784 patients (mean age 70.2 years).

INTERVENTION

ESD procedures were performed using typical sequences.

MAIN OUTCOME MEASUREMENTS

Risk factors related to resectability (en bloc or piecemeal resection) and curability (curative or noncurative resection) after ESD were analyzed using logistic regression analysis. Using this model, we constructed a risk assessment chart to predict the probability of noncurability from patient characteristics.

RESULTS

The en bloc and curative resection rates were 98.9% and 88.1%, respectively, after ESD. Significant contributors to noncurative ESD were large lesions, upper location, and ulcer findings. Predicted noncurability probabilities were displayed in 4 colors for each risk level (light blue, blue, yellow, and red) by combining tumor size, tumor location, and ulcer findings. Probability of noncurability was highest (≥ 40%) in ulcerative large tumors (>30 mm in diameter) in the upper location (red) and lowest in nonulcerative small tumors (≤ 20 mm in diameter) in the lower location (light blue).

LIMITATIONS

Retrospective design and single-site data collection.

CONCLUSIONS

This risk assessment chart shows individuals their pretreatment curability assessment with successful ESD and may be an educational tool for trainees or a decision-making tool.