H. Lee Moffitt Cancer Center and Research Institute, Cancer Epidemiology Program, 12902 Magnolia Drive MRC-CANCONT, Tampa, FL 33612, USA.
Cancer Epidemiol Biomarkers Prev. 2012 Jan;21(1):102-10. doi: 10.1158/1055-9965.EPI-11-0591. Epub 2011 Oct 20.
The influence of smoking on the natural history of HPV infection in men is not well understood. Smoking could influence the incidence and persistence of HPV infections by suppressing local immune function, increased cellular proliferation, upregulated proinflammatory factors, or induced host DNA damage resulting in increased susceptibility to infection. The purpose of this analysis is to assess prevalent HPV infections by smoking status in men, and to determine baseline risk of HPV infection associated with smoking.
The HPV in Men (HIM) study is a multinational prospective study of the natural history of HPV infections in men. Samples from the coronal sulcus, glans penis, shaft, and scrotum were combined for HPV DNA testing. Multivariable logistic regression was used to assess the association between smoking and any-, oncogenic-, and nononcogenic HPV infections.
Our analyses revealed that current smoking was associated with an increased risk of any HPV infection (OR = 1.19; 95% CI: 1.01-1.41) and oncogenic HPV infection (OR = 1.24; 95% CI: 1.05-1.47). However, the association between smoking and any HPV infection (OR = 1.35; 95% CI: 1.05-1.73) and oncogenic HPV infection (OR = 1.46; 95% CI: 1.11-1.92) was only evident among men reporting fewer lifetime sexual partners.
These results suggest that current smokers with the fewest number of sexual partners are associated with an increased risk for oncogenic HPV infection.
The relationship between smoking and HPV infection remains understudied in men; these data shed new light on the interplay between smoking, sexual activity, and risk of HPV infection.
吸烟对男性 HPV 感染自然史的影响尚不清楚。吸烟可能通过抑制局部免疫功能、增加细胞增殖、上调促炎因子或诱导宿主 DNA 损伤，从而增加感染易感性，从而影响 HPV 感染的发生率和持续性。本分析旨在评估吸烟状况与男性 HPV 感染的关系，并确定与吸烟相关的 HPV 感染的基线风险。
男性 HPV 研究（HIM）是一项评估 HPV 感染在男性中的自然史的多中心前瞻性研究。冠状沟、龟头、阴茎干和阴囊的样本被合并用于 HPV DNA 检测。多变量逻辑回归用于评估吸烟与任何、致癌性和非致癌性 HPV 感染之间的关系。
我们的分析表明，当前吸烟与任何 HPV 感染（OR = 1.19；95%CI：1.01-1.41）和致癌性 HPV 感染（OR = 1.24；95%CI：1.05-1.47）的风险增加相关。然而，吸烟与任何 HPV 感染（OR = 1.35；95%CI：1.05-1.73）和致癌性 HPV 感染（OR = 1.46；95%CI：1.11-1.92）之间的关联仅在报告性伴侣较少的男性中存在。
这些结果表明，性伴侣最少的当前吸烟者与致癌性 HPV 感染的风险增加相关。
吸烟与 HPV 感染之间的关系在男性中研究较少；这些数据为吸烟、性活动与 HPV 感染风险之间的相互作用提供了新的认识。
