Rao Rashmi P, Connolly Dana, Lamberti John J, Fripp Raymond, El Said Howaida
Division of Pediatric Cardiology Pediatric, Rady Children's Hospital, University of California San Diego, San Diego, Calif 92123, USA.
Congenit Heart Dis. 2012 Mar-Apr;7(2):160-9. doi: 10.1111/j.1747-0803.2011.00565.x. Epub 2011 Oct 21.
The purpose of this study was to establish an objective criterion to help assess adequacy of the transverse arch in newborns with coarctation and thereby optimize preoperative surgical decision making.
Echocardiograms of 47 patients < 6 months of age who underwent coarctation repair from September 2005 to November 2008 and 47 age-matched healthy infants were reviewed. The proximal and distal transverse aortic arch to descending aorta ratios (TAA:DAO ratio) were calculated from the end-systolic proximal and distal transverse aortic arch diameters and diameter of the descending aorta at the diaphragm.
Both the proximal and distal TAA:DAO ratios were significantly lower in the study vs. control group (P = .001) and in patients who underwent patch reconstruction of the aorta vs. extended end-to-end anastomosis (P = .014; P = .015). All patients who underwent patch reconstruction had a proximal and/or distal TAA:DAO < 0.65. A cutoff of 0.65 was derived based on our analyses and an algorithm was developed to guide decision making. Forty-six out of 47 patients were free from reintervention.
The TAA:DAO ratio appears to be an accurate parameter by which the adequacy of the transverse arch can be assessed preoperatively using the proposed algorithm, and thus help determine the type of surgical intervention and approach.
本研究的目的是建立一个客观标准,以帮助评估患有主动脉缩窄的新生儿的横弓是否足够,从而优化术前手术决策。
回顾了2005年9月至2008年11月期间接受主动脉缩窄修复术的47例6个月以下患者以及47例年龄匹配的健康婴儿的超声心动图。根据收缩末期近端和远端横主动脉弓直径以及膈肌水平降主动脉直径计算近端和远端横主动脉弓与降主动脉的比值(TAA:DAO比值)。
研究组与对照组相比,近端和远端TAA:DAO比值均显著降低(P = 0.001),接受主动脉补片重建的患者与接受延长端端吻合术的患者相比,近端和远端TAA:DAO比值也显著降低(P = 0.014;P = 0.015)。所有接受补片重建的患者近端和/或远端TAA:DAO均<0.65。根据我们的分析得出截断值为0.65,并开发了一种算法来指导决策。47例患者中有46例无需再次干预。
TAA:DAO比值似乎是一个准确的参数,通过使用所提出的算法可以在术前评估横弓是否足够,从而有助于确定手术干预的类型和方法。