Department of Allergy/Immunology, Walter Reed Army Medical Center, Washington, DC, USA.
Ann Allergy Asthma Immunol. 2011 Nov;107(5):437-40. doi: 10.1016/j.anai.2011.06.012. Epub 2011 Jul 27.
Cat extract allergen immunotherapy (AIT) is an effective treatment for cat allergy. The prescribed dose for cat AIT varies among prescribers, despite published data supporting an effective dose range. The original practice parameter published in December 1996 did not recommend a dose of cat allergen, but updates in January 2003 and September 2007 recommend cat extract dose ranges of 2,000 to 3,000 BAU and 1,000 to 4,000 BAU, respectively.
To describe the prescribing patterns for cat AIT among practicing allergists in a large health care system and the effect of practice parameters on these patterns.
A total of 27,788 prescriptions were analyzed to determine the date and amount of maintenance dose cat allergen prescribed. The data were subdivided into periods before and after the 3 published AIT practice parameters.
From January 2003 to September 2007, 1,810 prescriptions (18.0%) were written in the recommended range. From September 2007 to May 2009, 3,143 prescriptions (82.6%) were written in the recommended range. Cat AIT maintenance doses were 1,000 to 4,000 BAU 22.1% of the time before January 2003, 61.8% from January 2003 to September 2007, and 82.6% from September 2007 to May 2009.
In this large systemic evaluation of cat AIT prescribing patterns, maintenance dose recommendations in the AIT practice parameters were associated with changes in the prescribing patterns for cat AIT. Most prescriptions for cat AIT were inconsistent with recommended doses in the AIT practice parameters between 2003 and 2007. Dosing within recommended ranges improved after 2007, in part due to a widening of the recommended dose range.
猫提取物过敏原免疫疗法（AIT）是治疗猫过敏的有效方法。尽管有发表的数据支持有效的剂量范围，但不同的处方医生开出的猫 AIT 剂量却各不相同。1996 年 12 月发表的原始实践参数没有推荐猫过敏原剂量，但 2003 年 1 月和 2007 年 9 月的更新分别推荐猫提取物剂量范围为 2000 至 3000 BAU 和 1000 至 4000 BAU。
描述大型医疗保健系统中执业过敏症医生开出的猫 AIT 处方模式，以及实践参数对这些模式的影响。
共分析了 27788 张处方，以确定维持剂量猫过敏原的开具日期和剂量。这些数据分为发表的 3 个 AIT 实践参数前后两个时期进行细分。
从 2003 年 1 月至 2007 年 9 月，有 1810 张（18.0%）处方在推荐范围内开出。从 2007 年 9 月至 2009 年 5 月，有 3143 张（82.6%）处方在推荐范围内开出。在 2003 年 1 月之前，猫 AIT 维持剂量为 1000 至 4000 BAU 的时间占 22.1%，从 2003 年 1 月至 2007 年 9 月占 61.8%，从 2007 年 9 月至 2009 年 5 月占 82.6%。
在这项对猫 AIT 处方模式的大型系统评估中，AIT 实践参数中的维持剂量建议与猫 AIT 处方模式的变化相关。2003 年至 2007 年间，大多数猫 AIT 处方与 AIT 实践参数中的推荐剂量不一致。2007 年后，由于推荐剂量范围的扩大，推荐剂量范围内的剂量有所增加。
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