Suppr超能文献

TGF-β 信号通路在结直肠癌发生中的作用。

TGF-beta signalling in colon carcinogenesis.

机构信息

First Department of Surgery, Tzaneio General Hospital, Athens, Greece.

出版信息

Cancer Lett. 2012 Jan 1;314(1):1-7. doi: 10.1016/j.canlet.2011.09.041. Epub 2011 Oct 7.

Abstract

Colorectal cancer remains the most common cancer and the second leading cause of cancer mortality in Europe. There are a number of pathways that have been implicated in colorectal carcinogenesis, including TGF-beta (TGF-β)/Smad signalling pathway. The TGF-β pathway is involved in several biological processes, including cell proliferation, differentiation, migration and apoptosis. Here we review the role of TGF-β signalling cascade in colorectal carcinogenesis and provide some new molecular insights that may aid efforts towards targeted antitumor therapies.

摘要

结直肠癌仍然是欧洲最常见的癌症和第二大癌症死亡原因。有许多途径与结直肠癌的发生有关,包括 TGF-β(转化生长因子-β)/Smad 信号通路。TGF-β 途径参与多种生物学过程,包括细胞增殖、分化、迁移和凋亡。在这里,我们综述了 TGF-β 信号级联在结直肠癌发生中的作用,并提供了一些新的分子见解,可能有助于靶向抗肿瘤治疗的研究。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验