First Department of Surgery, Tzaneio General Hospital, Athens, Greece.
Cancer Lett. 2012 Jan 1;314(1):1-7. doi: 10.1016/j.canlet.2011.09.041. Epub 2011 Oct 7.
Colorectal cancer remains the most common cancer and the second leading cause of cancer mortality in Europe. There are a number of pathways that have been implicated in colorectal carcinogenesis, including TGF-beta (TGF-β)/Smad signalling pathway. The TGF-β pathway is involved in several biological processes, including cell proliferation, differentiation, migration and apoptosis. Here we review the role of TGF-β signalling cascade in colorectal carcinogenesis and provide some new molecular insights that may aid efforts towards targeted antitumor therapies.
结直肠癌仍然是欧洲最常见的癌症和第二大癌症死亡原因。有许多途径与结直肠癌的发生有关，包括 TGF-β（转化生长因子-β）/Smad 信号通路。TGF-β 途径参与多种生物学过程，包括细胞增殖、分化、迁移和凋亡。在这里，我们综述了 TGF-β 信号级联在结直肠癌发生中的作用，并提供了一些新的分子见解，可能有助于靶向抗肿瘤治疗的研究。
