Downward J, Graves J D, Warne P H, Rayter S, Cantrell D A
Signal Transduction Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
Nature. 1990 Aug 23;346(6286):719-23. doi: 10.1038/346719a0.
External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.
此前尚未鉴定出控制ras原癌基因所编码蛋白质活性的外部信号。现已表明，T淋巴细胞抗原受体的刺激会导致p21ras迅速激活。其机制似乎涉及在蛋白激酶C受到刺激时，GTP酶激活蛋白GAP的活性降低。因此，在淋巴细胞中，p21ras可能是蛋白激酶C作用的重要介质。
