Laboratory of Neuropathology, 1st Department of Neurology, School of Medicine, Aristotle University, 54636 Thessaloniki, Greece.
J Chem Neuroanat. 2012 Jan;43(1):20-7. doi: 10.1016/j.jchemneu.2011.10.002. Epub 2011 Oct 14.
Extensive alternative splicing is observed in the mammalian nervous system providing for protein diversity and specificity to accomplish the complex neuronal functions. Mechanisms underlying neuron specific splicing are not yet well understood. Among the factors regulating splicing of major importance are serine/arginine protein kinases (SRPKs) that phosphorylate SR splicing factors. SRPK1 is known to be expressed in the mammalian central nervous system. The present immunohistochemical study reveals a region- and neuron-specific localization of SRPK1 in human brain. The potential involvement of the kinase in the regulation of alternative splicing of various neuronal proteins is discussed.
在哺乳动物神经系统中观察到广泛的选择性剪接，为实现复杂的神经元功能提供了蛋白质多样性和特异性。神经元特异性剪接的机制尚不清楚。在调节剪接的重要因素中，丝氨酸/精氨酸蛋白激酶（SRPKs）是重要的一类，它们可以磷酸化 SR 剪接因子。已知 SRPK1 在哺乳动物中枢神经系统中表达。本免疫组织化学研究揭示了 SRPK1 在人脑内的区域和神经元特异性定位。讨论了激酶在调节各种神经元蛋白的选择性剪接中的潜在作用。
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