磷酸二酯酶与女性生殖功能的调节。

Phosphodiesterases and regulation of female reproductive function.

机构信息

Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, 513 Parnassus Avenue, HSW 1656, Box 0556, San Francisco, CA 94143-0556, United States.

出版信息

Curr Opin Pharmacol. 2011 Dec;11(6):665-9. doi: 10.1016/j.coph.2011.10.004. Epub 2011 Oct 21.

DOI:10.1016/j.coph.2011.10.004

PMID:22019564

Abstract

The function of the mammalian follicle is regulated by circulating gonadotropins and a myriad of local paracrine regulations functioning within the ovary. Cyclic nucleotide signaling plays an essential role in mediating both these endocrine and paracrine regulations. Given their role in controlling cyclic nucleotide levels, cyclic nucleotide phosphodiesterases (PDEs) are critical for ovarian function. PDEs modulate gonadotropin responses in the somatic compartment of the ovarian follicle. Specific PDEs are also essential for the oocyte entry and exit from the meiotic cell cycle. This review summarizes the function and regulation of PDEs in the somatic compartment and in the oocyte, and highlights the potential of PDEs as targets to improve assisted reproduction, as well as for fertility control.

摘要

哺乳动物卵泡的功能受循环性腺激素和卵巢内众多局部旁分泌调节的控制。环核苷酸信号转导在介导这些内分泌和旁分泌调节中起着至关重要的作用。鉴于它们在控制环核苷酸水平中的作用，环核苷酸磷酸二酯酶（PDEs）对于卵巢功能至关重要。PDEs 调节卵母细胞进入和退出减数分裂细胞周期。本文综述了 PDE 在卵巢滤泡体细胞区室和卵母细胞中的功能和调节作用，并强调了 PDE 作为提高辅助生殖和控制生育能力的靶点的潜力。