氟他胺可阻断青春期雄性大鼠促黄体生成激素释放激素的自启动效应。

Flutamide blocks the self-priming effect of luteinizing hormone-releasing hormone in pubertal male rats.

作者信息

Nazian S J

机构信息

Department of Physiology and Biophysics, College of Medicine, University of South Florida, Tampa 33612.

出版信息

Proc Soc Exp Biol Med. 1990 Sep;194(4):352-7. doi: 10.3181/00379727-194-43108.

DOI:10.3181/00379727-194-43108

PMID:2201967

Abstract

Castration of pubertal or young adult male rats eliminates the self-priming effect of luteinizing hormone-releasing hormone on luteinizing hormone secretion. Testosterone, dihydrotestosterone, or estradiol will maintain this effect in castrated animals. In order to explore the mechanism by which both dihydrotestosterone and estradiol are capable of maintaining the effect, intact rats as well as castrated animals implanted with testosterone capsules were treated with the antiandrogen Flutamide. In both intact animals and castrated rats bearing testosterone-filled Silastic capsules, Flutamide blocked the self-priming effect. These data suggest that the androgen receptor is of primary importance in the maintenance of the self-priming effect.

摘要

对青春期或成年雄性大鼠进行阉割会消除促黄体生成素释放激素对促黄体生成素分泌的自我启动效应。睾酮、双氢睾酮或雌二醇可在阉割动物中维持这种效应。为了探究双氢睾酮和雌二醇都能维持这种效应的机制，对完整大鼠以及植入睾酮胶囊的阉割动物用抗雄激素氟他胺进行处理。在完整动物和植入含睾酮硅橡胶胶囊的阉割大鼠中，氟他胺均阻断了自我启动效应。这些数据表明，雄激素受体在维持自我启动效应中至关重要。