Lemoine Sandrine, Rognant Nicolas, Collet-Benzaquen Diane, Juillard Laurent
Université de Lyon, 69008 Lyon, France.
Nephrol Ther. 2012 Jul;8(4):206-11. doi: 10.1016/j.nephro.2011.07.413. Epub 2011 Oct 22.
X-ray computer assisted tomography scanner is an imaging method based on the use of X-ray attenuation in tissue. This attenuation is proportional to the density of the tissue (without or after contrast media injection) in each pixel image of the image. Spiral scanner, the electron beam computed tomography (EBCT) scanner and multidetector computed tomography scanner allow renal anatomical measurements, such as cortical and medullary volume, but also the measurement of renal functional parameters, such as regional renal perfusion, renal blood flow and glomerular filtration rate. These functional parameters are extracted from the modeling of the kinetics of the contrast media concentration in the vascular space and the renal tissue, using two main mathematical models (the gamma variate model and the Patlak model). Renal functional imaging allows measuring quantitative parameters on each kidney separately, in a non-invasive manner, providing significant opportunities in nephrology, both for experimental and clinical studies. However, this method uses contrast media that may alter renal function, thus limiting its use in patients with chronic renal failure. Moreover, the increase irradiation delivered to the patient with multi detector computed tomography (MDCT) should be considered.
X射线计算机断层扫描仪是一种基于利用组织中X射线衰减的成像方法。这种衰减与图像每个像素中的组织密度(注射造影剂前后)成正比。螺旋扫描仪、电子束计算机断层扫描(EBCT)扫描仪和多探测器计算机断层扫描仪不仅可以进行肾脏解剖测量,如皮质和髓质体积,还可以测量肾脏功能参数,如局部肾灌注、肾血流量和肾小球滤过率。这些功能参数是通过使用两种主要数学模型(伽马变量模型和帕特拉克模型)对血管空间和肾组织中造影剂浓度动力学进行建模而提取的。肾脏功能成像能够以非侵入性方式分别测量每个肾脏的定量参数,为实验研究和临床研究在肾脏病学领域提供了重要机遇。然而,这种方法使用的造影剂可能会改变肾功能,因此限制了其在慢性肾衰竭患者中的应用。此外,还应考虑多探测器计算机断层扫描(MDCT)给患者带来的辐射增加问题。